Frontline Spot On ingredients
Frontline Spot On and Frontline Plus both use fipronil as their active ingredient, an insecticide that works by disrupting a flea or tick's nervous system on contact after it spreads across the pet's skin and coat. Frontline Plus adds a second ingredient, an insect growth regulator, which also targets flea eggs and larvae in the surrounding environment rather than just adult fleas on the pet.
How fipronil actually works
After application, fipronil spreads through the natural oils in a pet's skin and coat rather than being absorbed into the bloodstream, collecting in hair follicles and gradually releasing over several weeks. Fleas and ticks are affected on contact with the coat, which is why the product keeps working between applications rather than needing to be reapplied constantly.
This is a well-established, widely used ingredient in flea and tick treatments generally available without a prescription in the UK, matched to a pet's species and weight band on the pack. Always use the correct product for the species and size stated, since a treatment formulated for one is not automatically safe for the other.
What we stock
We stock a range of Frontline Spot On and Frontline Plus pack sizes for both dogs and cats, sized for different weight bands as set out on the packaging. Apply strictly according to the instructions printed on the pack for your pet's actual weight, and speak to your vet first if your pet is unwell, pregnant, nursing, or you are using any other flea or worm treatment alongside it.
Multi-pipette packs are worth considering if you are treating a pet on an ongoing monthly basis, since buying a single pipette repeatedly usually works out more expensive than a pack sized for several months at once. Whichever pack size you choose, always match the pipette to the current weight band of the individual pet it is for.
From this brand
Everything below is in stock with us, priced with delivery worked out, and packed and posted by hand in the UK.
Frontline Spot on Dog 3 Pipettes
Monthly fipronil spot-on flea and tick treatment for dogs, three pipettes
£30.49
Frontline Spot on Dog 1 Pipette
Monthly fipronil spot-on flea and tick treatment for dogs, single pipette
£11.35
Frontline Plus Dog 3 Pipettes
Frontline Plus spot-on flea and tick treatment for dogs, 3-pipette packs sized for medium or large
£34.89
Frontline Plus Small Dog - 1 Pipettes
Frontline Plus small-dog spot-on with fipronil and S-methoprene, for dogs weighing 2-10kg
£13.75
Frontline Plus Dog 1 Pipette
Frontline Plus spot-on for medium or large dogs, with fipronil and S-methoprene in size variants
£13.75
Frontline Plus Small Dog - 3 Pipette
A spot-on flea and tick treatment for small dogs, giving four weeks of protection per pipette
£34.89
Frontline Plus Large Dog - 6 Pipettes
6 pipettes of Frontline Plus spot-on for dogs 20-40kg, applied every 4 weeks
£57.59
Frontline Spot on Dog Medium - 6 Pipettes
Monthly spot-on flea and tick protection for medium dogs, 6 pipettes per pack
£49.99
Frontline Wormer Dog
Frontline Wormer dog tablets in two weight-specific variants, with two tablets per pack
From£8.15
Fleasolve Spot on Flea Treatment Dog
Vet-strength Fipronil spot-on flea and tick treatment, sized for large, medium or small dogs
From£6.19
Beaphar Fiprotec Combo Spot on for Dogs
Spot-on flea and tick treatment for dogs 20–40kg, three treatments per pack
From£9.33
Bob Martin Clear Plus Spot-On Flea, Tick & Lice Treatment Small Dogs
A two-ingredient spot-on for small dogs, 2-10kg, covering fleas, ticks and lice
£8.10
Common questions
- What is the active ingredient in Frontline Spot On?
- Fipronil is the active ingredient in both Frontline Spot On and Frontline Plus. It works by spreading through the natural oils in the coat and disrupting the nervous system of fleas and ticks on contact.
- What's the difference between Frontline Spot On and Frontline Plus?
- Frontline Plus contains fipronil alongside an additional insect growth regulator, which also targets flea eggs and larvae rather than only adult fleas. Frontline Spot On contains fipronil alone.
- Is Frontline safe for cats and dogs?
- Frontline products are formulated separately for cats and dogs and sized by weight band, and should only be used on the species and size stated on the specific pack. Always check the packaging matches your pet exactly and speak to your vet if you are ever unsure.
- Do I need a prescription for Frontline Spot On?
- No, Frontline Spot On and Frontline Plus are both available without a prescription in the UK. Always follow the instructions printed on the pack for your pet's weight, and speak to your vet if your pet has a health condition or is on other medication.
Related
Written by Matt Garnett, who runs Giddy Pets and is a lifelong pet owner — not a vet. This is general information, not veterinary advice, and it cannot replace an examination by the vet who knows your animal. How we write these guides.